Whole Animal Imaging
Imaging living animals is both an important stepping stone towards intraoperative imaging and an invaluable tool for biomedical research. Now, researchers studying cancer therapies in mice must choose between imprecise measurements made on living mice and sacrificing the animal for high-resolution imaging. We have developed high-resolution whole-animal in vivo systems for mouse and zebrafish imaging to offer an improved alternative.
C. Salthouse, S. Hildebrand, R. Weissleder, and U. Mahmood, "Design and Demonstration of a Small-Animal Up-Conversion Imager" Optics Express, vol. 16, no. 26, pp. 21731-21737, December 2008.
C. Salthouse, R. Upadhyay, R. Weissleder, and U. Mahmood, "In Vivo Discrimination of Two Far Red Dyes with Identical Absorption and Emission Spectra Based on Fluorescent Lifetime for Improved Multiplexing" presented at the Radiological Society of North America November 2007.
C. Salthouse, R. Upadhyay, R. Weissleder, and U. Mahmood, "Fluorescent Lifetime Discrimination of Activatable Probe Signal from Autofluorescence in Whole Mouse Imaging" presented at the Joint Society for Molecular Image / Academy of Molecular Imaging Conference September 2007.